What is the primary reason antibiotics are ineffective for long-term acne treatment?

The primary reason antibiotics are ineffective for long-term acne treatment is that acne is not inherently a bacterial issue. While the presence of bacteria, such as Propionibacterium acnes (P.acnes), plays a role in some cases of acne, the root causes are much more complex. Factors like hormonal fluctuations, excess oil production, skin cell turnover issues, and inflammation contribute significantly to the development of acne.

By addressing only the bacterial component with antibiotics, which can help reduce the number of bacteria on the skin, the treatment does not tackle the underlying factors that lead to acne formation. As a result, antibiotics may provide only temporary relief and are not a suitable solution for long-term acne management.